Development of Oseltamivir Phosphonate Congeners as Anti-Influenza Agents

Oseltamivir phosphonic acid (tamiphosphor, 3a), its monoethyl ester (3c), guanidino-tamiphosphor (4a) and its monoethyl ester (4c) are potent inhibitors of influenza neuraminidases. They inhibit the replication of influenza viruses, including the oseltamivir-resistant H275Y strain, at low nM to pM l...

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主要な著者: Cheng, Ting-Jen R., Weinheimer, Steven, Tarbet, E. Bart, Jan, Jia-Tsrong, Cheng, Yih-Shyun E., Shie, Jiun-Jie, Chen, Chun-Lin, Chen, Chih-An, Hsieh, Wei-Che, Huang, Pei-Wei, Lin, Wen-Hao, Wang, Shi-Yun, Fang, Jim-Min, Hu, Oliver Yoa-Pu, Wong, Chi-Huey
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492761/
https://ncbi.nlm.nih.gov/pubmed/23009169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3008486
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