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Crystal structure of adenovirus E3-19K bound to HLA-A2 reveals mechanism for immunomodulation
E3-19K binds to and retains MHC class I molecules in the endoplasmic reticulum, suppressing anti-Adenovirus (Ad) activities of T-cells. We determined the structure of the Ad serotype 2 (Ad2, species C) E3-19K–HLA-A2 complex to 1.95 Å resolution. Ad2 E3-19K binds to the N-terminus of the HLA-A2 groov...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492506/ https://ncbi.nlm.nih.gov/pubmed/23042604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2396 |
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