Enhanced Antitumor Efficacy and Reduced Systemic Toxicity of Sulfatide-Containing Nanoliposomal Doxorubicin in a Xenograft Model of Colorectal Cancer

Sulfatide is a glycosphingolipid known to interact with several extracellular matrix proteins, such as tenascin-C which is overexpressed in many types of cancer including that of the colon. In view of the limited success of chemotherapy in colorectal cancer and high toxicity of doxorubicin (DOX), a...

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Bibliographische Detailangaben
Hauptverfasser: Lin, Jia, Yu, Yan, Shigdar, Sarah, Fang, Ding Zhi, Du, Jun Rong, Wei, Ming Q., Danks, Andrew, Liu, Ke, Duan, Wei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492268/
https://ncbi.nlm.nih.gov/pubmed/23145140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049277
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