Use of Massively Parallel Pyrosequencing to Evaluate the Diversity of and Selection on Plasmodium falciparum csp T-Cell Epitopes in Lilongwe, Malawi

The development of an effective malaria vaccine has been hampered by the genetic diversity of commonly used target antigens. This diversity has led to concerns about allele-specific immunity limiting the effectiveness of vaccines. Despite extensive genetic diversity of circumsporozoite protein (CS),...

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Main Authors: Bailey, Jeffrey A., Mvalo, Tisungane, Aragam, Nagesh, Weiser, Matthew, Congdon, Seth, Kamwendo, Debbie, Martinson, Francis, Hoffman, Irving, Meshnick, Steven R., Juliano, Jonathan J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491736/
https://ncbi.nlm.nih.gov/pubmed/22551816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis329
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