Water Permeability of Aquaporin-4 Channel Depends on Bilayer Composition, Thickness, and Elasticity

Aquaporin-4 (AQP4) is the primary water channel in the mammalian brain, particularly abundant in astrocytes, whose plasma membranes normally contain high concentrations of cholesterol. Here we test the hypothesis that the water permeabilities of two naturally occurring isoforms (AQP4-M1 and AQP4-M23...

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Main Authors: Tong, Jihong, Briggs, Margaret M., McIntosh, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2012
Assuntos:
Membrane
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491688/
https://ncbi.nlm.nih.gov/pubmed/23199918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.09.025
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