Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

The 40-fold increase in childhood megakaryocyte-erythroid and B-cell leukemia in Down syndrome implicates trisomy 21 (T21) in perturbing fetal hematopoiesis. Here, we show that compared with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and megakaryocyte-eryth...

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Main Authors: Roy, Anindita, Cowan, Gillian, Mead, Adam J., Filippi, Sarah, Bohn, Georg, Chaidos, Aristeidis, Tunstall, Oliver, Chan, Jerry K. Y., Choolani, Mahesh, Bennett, Phillip, Kumar, Sailesh, Atkinson, Deborah, Wyatt-Ashmead, Josephine, Hu, Ming, Stumpf, Michael P. H., Goudevenou, Katerina, O'Connor, David, Chou, Stella T., Weiss, Mitchell J., Karadimitris, Anastasios, Jacobsen, Sten Eirik, Vyas, Paresh, Roberts, Irene
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491522/
https://ncbi.nlm.nih.gov/pubmed/23045701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211405109
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