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Pharmacological chaperones for human α-N-acetylgalactosaminidase
Schindler/Kanzaki disease is an inherited metabolic disease with no current treatment options. This neurologic disease results from a defect in the lysosomal α-N-acetylgalactosaminidase (α-NAGAL) enzyme. In this report, we show evidence that the iminosugar DGJNAc can inhibit, stabilize, and chaperon...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491485/ https://ncbi.nlm.nih.gov/pubmed/23045655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203924109 |
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