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Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis

Although the pimeloyl moiety was long known to be a biotin precursor, the mechanism of assembly of this C7 α,ω-dicarboxylic acid was only recently elucidated. In Escherichia coli, pimelate is made by bypassing the strict specificity of the fatty acid synthetic pathway. BioC methylates the free carbo...

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Detalles Bibliográficos
Main Authors: Agarwal, Vinayak, Lin, Steven, Lukk, Tiit, Nair, Satish K., Cronan, John E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491474/
https://ncbi.nlm.nih.gov/pubmed/23045647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207028109
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