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Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis
Although the pimeloyl moiety was long known to be a biotin precursor, the mechanism of assembly of this C7 α,ω-dicarboxylic acid was only recently elucidated. In Escherichia coli, pimelate is made by bypassing the strict specificity of the fatty acid synthetic pathway. BioC methylates the free carbo...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3491474/ https://ncbi.nlm.nih.gov/pubmed/23045647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207028109 |
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