Efficient −2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein

Programmed −1 ribosomal frameshifting (−1 PRF) is a gene-expression mechanism used to express many viral and some cellular genes. In contrast, efficient natural utilization of −2 PRF has not been demonstrated previously in eukaryotic systems. Like all nidoviruses, members of the Arteriviridae (a fam...

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Main Authors: Fang, Ying, Treffers, Emmely E., Li, Yanhua, Tas, Ali, Sun, Zhi, van der Meer, Yvonne, de Ru, Arnoud H., van Veelen, Peter A., Atkins, John F., Snijder, Eric J., Firth, Andrew E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
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PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491471/
https://ncbi.nlm.nih.gov/pubmed/23043113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211145109
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