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HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation

Host-cell factor 1 (HCF-1) is an unusual transcriptional regulator that undergoes a process of proteolytic maturation to generate N- (HCF-1(N)) and C- (HCF-1(C)) terminal subunits noncovalently associated via self-association sequence elements. Here, we present the crystal structure of the self-asso...

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מידע ביבליוגרפי
Main Authors: Park, Jihye, Lammers, Fabienne, Herr, Winship, Song, Ji-Joon
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491465/
https://ncbi.nlm.nih.gov/pubmed/23045687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208378109
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