CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease

Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the deacetylase, sirtuin 3 (SIRT3). Here we investigate a role for CNS Sirt3 in mitochondrial responses to reactive oxygen species (ROS)- and Alzhei...

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Hauptverfasser: Weir, Heather J. M., Murray, Tracey K., Kehoe, Patrick G., Love, Seth, Verdin, Eric M., O’Neill, Michael J., Lane, Jon D., Balthasar, Nina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491018/
https://ncbi.nlm.nih.gov/pubmed/23139766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048225
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