Poly (I:C), an agonist of toll-like receptor-3, inhibits replication of the Chikungunya virus in BEAS-2B cells

BACKGROUND: Double-stranded RNA (dsRNA) and its mimic, polyinosinic acid: polycytidylic acid [Poly (I:C)], are recognized by toll-like receptor 3 (TLR3) and induce interferon (IFN)-β in many cell types. Poly (I:C) is the most potent IFN inducer. In in vivo mouse studies, intraperitoneal injection of...

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Detalhes bibliográficos
Main Authors: Li, Yong-Gang, Siripanyaphinyo, Uamporn, Tumkosit, Uranan, Noranate, Nitchakarn, A-nuegoonpipat, Atchareeya, Pan, Yang, Kameoka, Masanori, Kurosu, Takeshi, Ikuta, Kazuyoshi, Takeda, Naokazu, Anantapreecha, Surapee
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490739/
https://ncbi.nlm.nih.gov/pubmed/22698190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-9-114
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