Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site

BACKGROUND: The CD4 binding site (CD4bs) of envelope glycoprotein (Env) gp120 is a functionally conserved, important target of anti-human immunodeficiency virus type 1 (HIV-1) neutralizing antibodies. Two neutralizing human monoclonal antibodies, IgG1 b12 (b12) and VRC01, are broadly reactive neutra...

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Autors principals: Utachee, Piraporn, Isarangkura-na-ayuthaya, Panasda, Tokunaga, Kenzo, Ikuta, Kazuyoshi, Takeda, Naokazu, Kameoka, Masanori
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003292/
https://ncbi.nlm.nih.gov/pubmed/24758333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-32
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