Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

OBJECTIVE: The lesions of Parkinson's disease spread through the brain in a characteristic pattern that corresponds to axonal projections. Previous observations suggest that misfolded α-synuclein could behave as a prion, moving from neuron to neuron and causing endogenous α-synuclein to misfold...

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Auteurs principaux: Freundt, Eric C., Maynard, Nate, Clancy, Eileen K., Roy, Shyamali, Bousset, Luc, Sourigues, Yannick, Covert, Markus, Melki, Ronald, Kirkegaard, Karla, Brahic, Michel
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490229/
https://ncbi.nlm.nih.gov/pubmed/23109146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23747
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