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Comparison of mutated JAK2 and ABL1 as oncogenes and drug targets in myeloproliferative disorders
Constitutively activated mutants of the non-receptor tyrosine kinases (TK) ABL1 and JAK2 play a central role in the pathogenesis of clinically and morphologically distinct chronic myeloproliferative disorders but are also found in some cases of de novo acute leukemia and lymphoma. Ligand-independent...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3490192/ https://ncbi.nlm.nih.gov/pubmed/18528425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2008.133 |
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