DISRUPTION OF CIRCADIAN RHYTHMICITY AND SUPRACHIASMATIC ACTION POTENTIAL FREQUENCY IN A MOUSE MODEL WITH CONSTITUTIVE ACTIVATION OF GLYCOGEN SYNTHASE KINASE-3

Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in psychiatric diseases, neurodevelopment, and circadian regulation. Both GSK3 isoforms, α and β, exhibit a 24-hour variation of inhibitory phosphorylation within the suprachiasmatic nucleus (SCN), the primary ci...

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Hlavní autoři: Paul, Jodi R., Johnson, Russell L., Jope, Richard S., Gamble, Karen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490018/
https://ncbi.nlm.nih.gov/pubmed/22986169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.08.047
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