Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

For the eventual purpose of isolating and studying a single animal cell replicon, we have developed a methotrexate-resistant Chinese hamster ovary cell line that has amplified an early-replicating DNA sequence approximately 500 times; this sequence includes the gene coding for dihydrofolate reductas...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Milbrandt, J D, Heintz, N H, White, W C, Rothman, S M, Hamlin, J L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1981
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348973/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6273843/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.10.6043
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