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Treatment with a Nitric Oxide-Donating NSAID Alleviates Functional Muscle Ischemia in the Mouse Model of Duchenne Muscular Dystrophy

In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystrophin deficiency causes loss of neuronal nitric oxide synthase (nNOSμ) from the sarcolemma, producing functional ischemia when the muscles are exercised. We asked if functional muscle ischemia would be e...

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Detalhes bibliográficos
Main Authors: Thomas, Gail D., Ye, Jianfeng, De Nardi, Claudio, Monopoli, Angela, Ongini, Ennio, Victor, Ronald G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489726/
https://ncbi.nlm.nih.gov/pubmed/23139842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049350
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