Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

BACKGROUND: The Wnt/β-catenin signalling is aberrantly activated in primary B cell chronic lymphocytic leukaemia (CLL). Epigenetic silencing of pathway inhibitor genes may be a mechanism for its activation. In this study, we investigated systematically and quantitatively the methylation status of 12...

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Detalhes bibliográficos
Main Authors: Moskalev, Evgeny A, Luckert, Katrin, Vorobjev, Ivan A, Mastitsky, Sergey E, Gladkikh, Aleena A, Stephan, Achim, Schrenk, Marita, Kaplanov, Kamil D, Kalashnikova, Olga B, Pötz, Oliver, Joos, Thomas O, Hoheisel, Jörg D
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489542/
https://ncbi.nlm.nih.gov/pubmed/22672427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-213
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