Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration

Airway smooth muscle cell (ASMC) remodeling contributes to the structural changes in the airways that are central to the clinical manifestations of asthma. Ca(2+) signals play an important role in ASMC remodeling through control of ASMC migration and hypertrophy/proliferation. Upregulation of STIM1...

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Autori principali: Spinelli, Amy M., González-Cobos, José C., Zhang, Xuexin, Motiani, Rajender K., Rowan, Sarah, Zhang, Wei, Garrett, Joshua, Vincent, Peter A., Matrougui, Khalid, Singer, Harold A., Trebak, Mohamed
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3489062/
https://ncbi.nlm.nih.gov/pubmed/23014880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-012-1160-5
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