Protein Kinase C-α and Arginase I Mediate Pneumolysin-Induced Pulmonary Endothelial Hyperpermeability

Antibiotics-induced release of the pore-forming virulence factor pneumolysin (PLY) in patients with pneumococcal pneumonia results in its presence days after lungs are sterile and is a major factor responsible for the induction of permeability edema. Here we sought to identify major mechanisms media...

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Main Authors: Lucas, Rudolf, Yang, Guang, Gorshkov, Boris A., Zemskov, Evgeny A., Sridhar, Supriya, Umapathy, Nagavedi S., Jezierska-Drutel, Agnieszka, Alieva, Irina B., Leustik, Martin, Hossain, Hamid, Fischer, Bernhard, Catravas, John D., Verin, Alexander D., Pittet, Jean-François, Caldwell, Ruth B., Mitchell, Timothy J., Cederbaum, Stephen D., Fulton, David J., Matthay, Michael A., Caldwell, Robert W., Romero, Maritza J., Chakraborty, Trinad
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488628/
https://ncbi.nlm.nih.gov/pubmed/22582175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0332OC
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