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Neuromodulation of Thought: Flexibilities and Vulnerabilities in Prefrontal Cortical Network Synapses

In this review, we discuss how working memory prefrontal cortical (PFC) circuits are modulated differently than plastic changes in sensory/motor and subcortical circuits. Working memory arises from recurrent excitation within layer III PFC pyramidal cell NMDA circuits, which are afflicted in aging a...

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Detalhes bibliográficos
Main Authors: Arnsten, Amy F.T., Wang, Min J., Paspalas, Constantinos D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488343/
https://ncbi.nlm.nih.gov/pubmed/23040817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.08.038
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