Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

NF-E2-related factor 2 (Nrf2) is a key transcription factor that is critical for cellular defense against oxidative and xenobiotic insults. Nrf2 heterodimerizes with small Maf (sMaf) proteins and binds to antioxidant response elements (AREs) to activate a battery of cytoprotective genes. However, it...

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Autores principales: Hirotsu, Yosuke, Katsuoka, Fumiki, Funayama, Ryo, Nagashima, Takeshi, Nishida, Yuichiro, Nakayama, Keiko, Douglas Engel, James, Yamamoto, Masayuki
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488259/
https://ncbi.nlm.nih.gov/pubmed/22965115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks827
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