Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase

Peptidyl-tRNA hydrolase (Pth) cleaves the ester bond between the peptide and the tRNA of peptidyl-tRNA molecules, which are produced by aborted translation, to recycle tRNA for further rounds of protein synthesis. Pth is ubiquitous in nature, and its enzymatic activity is essential for bacterial via...

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Bibliographic Details
Main Authors: Ito, Kosuke, Murakami, Ryo, Mochizuki, Masahiro, Qi, Hao, Shimizu, Yoshihiro, Miura, Kin-ichiro, Ueda, Takuya, Uchiumi, Toshio
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488237/
https://ncbi.nlm.nih.gov/pubmed/22923517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks790
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