Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

DNA methylation is an essential mechanism controlling gene expression during differentiation and development. We investigated the epigenetic regulation of the nuclear-encoded, mitochondrial DNA (mtDNA) polymerase γ catalytic subunit (PolgA) by examining the methylation status of a CpG island within...

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Detalhes bibliográficos
Main Authors: Kelly, Richard D. W., Mahmud, Arsalan, McKenzie, Matthew, Trounce, Ian A., St John, Justin C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488228/
https://ncbi.nlm.nih.gov/pubmed/22941637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks770
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