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Revealing the Ligand Binding Site of NhaA Na(+)/H(+) Antiporter and Its pH Dependence
pH and Na(+) homeostasis in all cells requires Na(+)/H(+) antiporters. In most cases, their activity is tightly pH-regulated. NhaA, the main antiporter of Escherichia coli, has homologues in all biological kingdoms. The crystal structure of NhaA provided insights into the mechanism of action and pH...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3488084/ https://ncbi.nlm.nih.gov/pubmed/22915592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391128 |
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