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Revealing the Ligand Binding Site of NhaA Na(+)/H(+) Antiporter and Its pH Dependence

pH and Na(+) homeostasis in all cells requires Na(+)/H(+) antiporters. In most cases, their activity is tightly pH-regulated. NhaA, the main antiporter of Escherichia coli, has homologues in all biological kingdoms. The crystal structure of NhaA provided insights into the mechanism of action and pH...

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Autori principali: Maes, Michal, Rimon, Abraham, Kozachkov-Magrisso, Lena, Friedler, Assaf, Padan, Etana
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488084/
https://ncbi.nlm.nih.gov/pubmed/22915592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391128
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