Vascular Bioactivation of Nitroglycerin by Aldehyde Dehydrogenase-2: REACTION INTERMEDIATES REVEALED BY CRYSTALLOGRAPHY AND MASS SPECTROMETRY

Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactivation of nitroglycerin (glyceryl trinitrate, GTN) in blood vessels, resulting in vasodilation by nitric oxide (NO) or a related species. Because the mechanism of this reaction is still unclear we determined the three-dimensional structures of wi...

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Detalhes bibliográficos
Main Authors: Lang, Barbara S., Gorren, Antonius C. F., Oberdorfer, Gustav, Wenzl, M. Verena, Furdui, Cristina M., Poole, Leslie B., Mayer, Bernd, Gruber, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488082/
https://ncbi.nlm.nih.gov/pubmed/22988236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371716
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