High Selectivity of the γ-Aminobutyric Acid Transporter 2 (GAT-2, SLC6A13) Revealed by Structure-based Approach

The solute carrier 6 (SLC6) is a family of ion-dependent transporters that mediate uptake into the cell of osmolytes such as neurotransmitters and amino acids. Four SLC6 members transport GABA, a key neurotransmitter that triggers inhibitory signaling pathways via various receptors (e.g., GABA(A))....

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Main Authors: Schlessinger, Avner, Wittwer, Matthias B., Dahlin, Amber, Khuri, Natalia, Bonomi, Massimiliano, Fan, Hao, Giacomini, Kathleen M., Sali, Andrej
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Computational Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488050/
https://ncbi.nlm.nih.gov/pubmed/22932902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.388157
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