Structure, Sulfatide Binding Properties, and Inhibition of Platelet Aggregation by a Disabled-2 Protein-derived Peptide

Disabled-2 (Dab2) targets membranes and triggers a wide range of biological events, including endocytosis and platelet aggregation. Dab2, through its phosphotyrosine-binding (PTB) domain, inhibits platelet aggregation by competing with fibrinogen for α(IIb)β(3) integrin receptor binding. We have rec...

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Detalhes bibliográficos
Main Authors: Xiao, Shuyan, Charonko, John J., Fu, Xiangping, Salmanzadeh, Alireza, Davalos, Rafael V., Vlachos, Pavlos P., Finkielstein, Carla V., Capelluto, Daniel G. S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488045/
https://ncbi.nlm.nih.gov/pubmed/22977233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.385609
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