Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma

BACKGROUND: The histone deacetylase inhibitor vorinostat is a candidate radiosensitizer in locally advanced rectal cancer (LARC). Radiosensitivity is critically influenced by hypoxia; hence, it is important to evaluate the efficacy of potential radiosensitizers under variable tissue oxygenation. Sin...

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Bibliografiske detaljer
Main Authors: Saelen, Marie Grøn, Ree, Anne Hansen, Kristian, Alexandr, Fleten, Karianne Giller, Furre, Torbjørn, Hektoen, Helga Helseth, Flatmark, Kjersti
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488009/
https://ncbi.nlm.nih.gov/pubmed/23017053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-7-165
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