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Multi-scale agent-based brain cancer modeling and prediction of TKI treatment response: Incorporating EGFR signaling pathway and angiogenesis

BACKGROUND: The epidermal growth factor receptor (EGFR) signaling pathway and angiogenesis in brain cancer act as an engine for tumor initiation, expansion and response to therapy. Since the existing literature does not have any models that investigate the impact of both angiogenesis and molecular s...

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Detalhes bibliográficos
Main Authors: Sun, Xiaoqiang, Zhang, Le, Tan, Hua, Bao, Jiguang, Strouthos, Costas, Zhou, Xiaobo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487967/
https://ncbi.nlm.nih.gov/pubmed/22935054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-218
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