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GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice

OBJECTIVE: In addition to improve glucose intolerance, recent studies suggest that glucagon-like peptide-1 (GLP-1) receptor agonism also decreases triglyceride (TG) levels. The aim of this study was to evaluate the effect of GLP-1 receptor agonism on very-low-density lipoprotein (VLDL)-TG production...

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Detalhes bibliográficos
Main Authors: Parlevliet, Edwin T., Wang, Yanan, Geerling, Janine J., Schröder-Van der Elst, Janny P., Picha, Kristen, O'Neil, Karyn, Stojanovic-Susulic, Vedrana, Ort, Tatiana, Havekes, Louis M., Romijn, Johannes A., Pijl, Hanno, Rensen, Patrick C. N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487842/
https://ncbi.nlm.nih.gov/pubmed/23133675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049152
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