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Staphylococcal alpha-toxin: oligomerization of hydrophilic monomers to form amphiphilic hexamers induced through contact with deoxycholate detergent micelles.

Native staphylococcus aureus alpha-toxin is secreted as a hydrophilic polypeptide chain of Mr 34,000. The presence of deoxycholate above the critical micellar concentration induced the toxin monomers to self-associate, forming ring or cylindrical oligomers. The oligomers were amphiphilic and bound d...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Bhakdi, S, Füssle, R, Tranum-Jensen, J
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1981
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348768/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6272304/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.9.5475
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