Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid.
The leucine analog beta-2-aminobicyclo[2.2.1]heptane-2-carboxylic acid (BCH) activates glutamate dehydrogenase [L-glutamate:NAD+ oxidoreductase (deaminating), EC 1.4.1.2] in pancreatic islet homogenates. In intact islets, BCH increased the islet content or output of NH4+, 2-ketoglutarate, malate, py...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1981
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348765/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6117857/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.9.5460 |
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