Sildenafil Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells via Distinct Signaling Pathways

Sildenafil is a cGMP-specific phosphodiesterase type 5 inhibitor that augments cGMP accumulation following the activation of soluble guanylate cyclase (sGC). In this study, we investigated whether sildenafil promotes the production of the sGC-stimulatory gases, carbon monoxide and nitric oxide, by s...

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Hlavní autoři: Liu, Xiao-ming, Peyton, Kelly J., Wang, Xinhui, Durante, William
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487387/
https://ncbi.nlm.nih.gov/pubmed/22864061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.07.023
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