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Interferon-gamma induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1)

Interferon-gamma (IFN-γ) is a pleiotropic cytokine with immunomodulatory, anti-viral, and anti-proliferative effects. In this study, we examined the effects of IFN-γ on autophagy and cell growth in human hepatocellular carcinoma (HCC) cells. IFN-γ inhibited cell growth of Huh7 cells with non-apoptot...

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Detalhes bibliográficos
Main Authors: Li, Peiyuan, Du, Qiang, Cao, Zongxian, Guo, Zhong, Evankovich, John, Yan, Wei, Chang, Ying, Shao, Lifang, Stolz, Donna Beer, Tsung, Allan, Geller, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487386/
https://ncbi.nlm.nih.gov/pubmed/22056812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.09.031
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