The Thyroid Hormone Receptor Alpha Locus and White Matter Lesions: A Role for the Clock Gene REV-ERBα

BACKGROUND: Thyroid disorders are associated with an increased risk of cognitive impairment and Alzheimer's disease. Both small vessel disease and neurodegeneration have a role in the pathogenesis of cognitive impairment and Alzheimer's disease. Thyroid hormone receptor alpha (TRα) is the...

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Detalhes bibliográficos
Main Authors: Medici, Marco, Ikram, M. Arfan, van der Lijn, Fedde, den Heijer, Tom, Vernooij, Meike W., Hofman, Albert, Niessen, Wiro J., Visser, Theo J., Breteler, Monique M.B., Peeters, Robin P.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487114/
https://ncbi.nlm.nih.gov/pubmed/23083441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2012.0198
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