Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.
Two distinct loci that confer resistance to acycloguanosine (acyclo-Guo) in herpes simplex virus types 1 have been identified. The first locus is the gene for the virus-specific thymidine kinase (TK). Mutations that decrease TK activity also render the virus resistant to acyclo-Guo, and the level of...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1980
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348694/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6246531/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.4.2265 |
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