Use of Xylitol To Enhance the Therapeutic Efficacy of Polymethylmethacrylate-Based Antibiotic Therapy in Treatment of Chronic Osteomyelitis

Using a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin under in vivo conditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the tre...

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Detalhes bibliográficos
Main Authors: Beenken, Karen E., Bradney, Laura, Bellamy, William, Skinner, Robert A., McLaren, Sandra G., Gruenwald, M. Johannes, Spencer, Horace J., Smith, James K., Haggard, Warren O., Smeltzer, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Biologic Response Modifiers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486578/
https://ncbi.nlm.nih.gov/pubmed/22948866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01127-12
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