Kinetic and Crystallographic Studies of Extended-Spectrum GES-11, GES-12, and GES-14 β-Lactamases

GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been disc...

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Detalhes bibliográficos
Main Authors: Delbrück, Heinrich, Bogaerts, Pierre, Kupper, Michaël B., Rezende de Castro, Roberta, Bennink, Sandra, Glupczynski, Youri, Galleni, Moreno, Hoffmann, Kurt M., Bebrone, Carine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486532/
https://ncbi.nlm.nih.gov/pubmed/22908160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01272-12
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