The Asian-American E6 Variant Protein of Human Papillomavirus 16 Alone Is Sufficient To Promote Immortalization, Transformation, and Migration of Primary Human Foreskin Keratinocytes

We examined how well the human papillomavirus (HPV) E6 oncogene can function in the absence of the E7 oncogene during the carcinogenic process in human keratinocytes using a common HPV variant strongly associated with cervical cancer: the Asian-American E6 variant (AAE6). This E6 variant is 20 times...

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Bibliographische Detailangaben
Hauptverfasser: Niccoli, Sarah, Abraham, Suraj, Richard, Christina, Zehbe, Ingeborg
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Transformation and Oncogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486486/
https://ncbi.nlm.nih.gov/pubmed/22951839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01512-12
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