Deletion of the Herpes Simplex Virus 1 U(L)49 Gene Results in mRNA and Protein Translation Defects That Are Complemented by Secondary Mutations in U(L)41

Herpes simplex virus 1 (HSV-1) virions, like those of all herpesviruses, contain a protein layer termed the tegument localized between the capsid and the envelope. VP22, encoded by the U(L)49 gene, is one of the most abundant tegument proteins in HSV-1 virions. Studies with a U(L)49-null mutant show...

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Detalhes bibliográficos
Main Authors: Mbong, Ekaette F., Woodley, Lucille, Dunkerley, Eric, Schrimpf, Jane E., Morrison, Lynda A., Duffy, Carol
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486455/
https://ncbi.nlm.nih.gov/pubmed/22951838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01975-12
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