Identification of a Varicella-Zoster Virus Replication Inhibitor That Blocks Capsid Assembly by Interacting with the Floor Domain of the Major Capsid Protein

A novel anti-varicella-zoster virus compound, a derivative of pyrazolo[1,5-c]1,3,5-triazin-4-one (coded as 35B2), was identified from a library of 9,600 random compounds. This compound inhibited both acyclovir (ACV)-resistant and -sensitive strains. In a plaque reduction assay under conditions in wh...

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Autori principali: Inoue, Naoki, Matsushita, Misato, Fukui, Yoshiko, Yamada, Souichi, Tsuda, Mihoko, Higashi, Chizuka, Kaneko, Keiko, Hasegawa, Hideki, Yamaguchi, Toyofumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486443/
https://ncbi.nlm.nih.gov/pubmed/22933294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01280-12
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