Identification of a Varicella-Zoster Virus Replication Inhibitor That Blocks Capsid Assembly by Interacting with the Floor Domain of the Major Capsid Protein

A novel anti-varicella-zoster virus compound, a derivative of pyrazolo[1,5-c]1,3,5-triazin-4-one (coded as 35B2), was identified from a library of 9,600 random compounds. This compound inhibited both acyclovir (ACV)-resistant and -sensitive strains. In a plaque reduction assay under conditions in wh...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Inoue, Naoki, Matsushita, Misato, Fukui, Yoshiko, Yamada, Souichi, Tsuda, Mihoko, Higashi, Chizuka, Kaneko, Keiko, Hasegawa, Hideki, Yamaguchi, Toyofumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486443/
https://ncbi.nlm.nih.gov/pubmed/22933294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01280-12
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados