Establishment of a Cell-Based Assay for Screening of Compounds Inhibiting Very Early Events in the Cytomegalovirus Replication Cycle and Characterization of a Compound Identified Using the Assay

To simplify the detection of infectious human cytomegalovirus (HCMV), we generated a cell line that produced luciferase in a dose-dependent manner upon HCMV infection. Using this cell line, we identified anti-HCMV compounds from a diverse library of 9,600 compounds. One of them, 1-(3,5-dichloro-4-py...

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Hlavní autoři: Fukui, Yoshiko, Shindoh, Keiko, Yamamoto, Yumiko, Koyano, Shin, Kosugi, Isao, Yamaguchi, Toyofumi, Kurane, Ichiro, Inoue, Naoki
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443885/
https://ncbi.nlm.nih.gov/pubmed/18458124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00134-08
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