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Effect of introduction of small alkyl groups on mRNA function.

Treatment of RNA with dimethyl sulfate methylates only nitrogens, preferentially the 7 position of guanosine, whereas treatment with ethylnitrosourea ethylates mainly oxygens, preferentially the phosphodiester groups. Two plant viral mRNAs were modified with these two reagents at levels of 4-28 alky...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Fraenkel-Conrat, H, Singer, B
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1980
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348634/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6929532/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.4.1983
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