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Identification of the HIV-1 NC Binding Interface in Alix Bro1 Reveals a Role for RNA
HIV-1 recruits members of ESCRT, the cell membrane fission machinery that promotes virus exit. HIV-1 Gag protein gains access to ESCRT directly by binding Alix, an ESCRT-associated protein that promotes budding. The Alix Bro1 and V domains bind Gag NC and p6 regions, respectively. Whereas V-p6 bindi...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3486338/ https://ncbi.nlm.nih.gov/pubmed/22896625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01260-12 |
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