Polymorphisms in Toll-Like Receptor 4 Underlie Susceptibility to Tumor Induction by the Mouse Polyomavirus

PERA/Ei (PE) mice are susceptible to tumor induction by polyomavirus (Py), while C57BR/cdJ (BR) mice are resistant. Antigen-presenting cells from BR mice respond to the virus with interleukin-12 (IL-12) and those from PE mice with IL-10. These polarized cytokine responses underlie the development of...

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Main Authors: Velupillai, Palanivel, Sung, Chang Kyoo, Andrews, Erik, Moran, Jennifer, Beier, David, Kagan, Jonathan, Benjamin, Thomas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486304/
https://ncbi.nlm.nih.gov/pubmed/22896604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01614-12
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