Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target

Phosphatidylinositol-4-kinase IIIα (PI4KIIIα) is an essential host cell factor for hepatitis C virus (HCV) replication. An N-terminally truncated 130-kDa form was used to reconstitute an in vitro biochemical lipid kinase assay that was optimized for small-molecule compound screening and identified p...

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Autors principals: Vaillancourt, Frédéric H., Brault, Martine, Pilote, Louise, Uyttersprot, Nathalie, Gaillard, Elias T., Stoltz, James H., Knight, Brian L., Pantages, Lynn, McFarland, Mary, Breitfelder, Steffen, Chiu, Tim T., Mahrouche, Louiza, Faucher, Anne-Marie, Cartier, Mireille, Cordingley, Michael G., Bethell, Richard C., Jiang, Huiping, White, Peter W., Kukolj, George
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486294/
https://ncbi.nlm.nih.gov/pubmed/22896614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01320-12
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