Full-Length HIV-1 Immunogens Induce Greater Magnitude and Comparable Breadth of T Lymphocyte Responses to Conserved HIV-1 Regions Compared with Conserved-Region-Only HIV-1 Immunogens in Rhesus Monkeys

A global HIV-1 vaccine will likely need to induce immune responses against conserved HIV-1 regions to contend with the profound genetic diversity of HIV-1. Here we evaluated the capacity of immunogens consisting of only highly conserved HIV-1 sequences that are aimed at focusing cellular immune resp...

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Autores principales: Stephenson, Kathryn E., SanMiguel, Adam, Simmons, Nathaniel L., Smith, Kaitlin, Lewis, Mark G., Szinger, James J., Korber, Bette, Barouch, Dan H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486282/
https://ncbi.nlm.nih.gov/pubmed/22896617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01779-12
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